浜松医科大学TOP 矢印2 光医学総合研究所 矢印2 尖端研究支援部門

研究設備データベース

学内専用

先進機器共用推進部が管理

設置場所別共用機器(料金)

設備機器種類別共用機器(料金)

競争的研究費取扱共用機器(料金)

学内研究室が管理

機器(共用･譲渡可)リスト

学外リンク
大学連携研究設備ネットワーク
先進機器共用推進部(ARFS)

先進機器研究推進室(LPAR)

LPARでは、ARFSの設備を活用し、学内の研究グループとの共同研究を推進することにより、本学の基礎および臨床医学研究に貢献することを目的としています。例えば、がんを主とするヒト疾患の原因となる、細胞周期制御因子の機能異常に注目し共同研究を行っています。

The aim of LPAR is to contribute to promoting the basic and clinical research through utilization of instruments in ARFS and inter-departmental collaboration. One of our collaborative topics is the dysfunction of the cell cycle regulators, which could be a cause of several human diseases including cancers and chronic disorders.

Contact:
Chiharu Uchida,Ph.D. AssociateProfessor
cuchida(at)hama-med.ac.jp

先進機器研究推進室に関連する主な論文

*責任著者
  1. Suzuki T, Sakai T*, Ota K, Yoshida M, Uchida C, Niida H, Suda T, Kitagawa M, Ohhata T*: Expression of Tumor Suppressor FHIT Is Regulated by the LINC00173-SNAIL Axis in Human Lung Adenocarcinoma. International journal of molecular sciences 24(23), 2023. doi: 10.3390/ijms242317011.
  2. Suzuki M, Sakai S, Ota K, Bando Y, UchidaC, Niida H, Kitagawa M, Ohhata T*: CCIVR2 facilitates comprehensive identification of both overlapping and non-overlapping antisense transcripts within specified regions. Scientific reports 13(1) 14807-14807, 2023. doi: 10.1038/s41598-023-42044-x
  3. UchidaC*, Niida H, Sakai S, Iijima K, Kitagawa K, Ohhata T, Shiotani B, Kitagawa M.: p130RB2 positively contributes to ATR activation in response to replication stress via the RPA32-ETAA1 axis. Biochim. Biophys. Acta Mol. Cell Res. 1870(6):119484, 2023. doi: 10.1016/j.bbamcr.2023.119484. doi: 10.1111/pcmr.13102.
  4. Ota K, Sakai S*, Ohhata T, Suzuki T, UchidaC, Niida H, Kitagawa M*.: APOBEC3B expression is promoted by lincNMR collaborating with TGF-β-Smad pathway. Carcinogenesis. 44(1):1-14, 2023. doi: 10.1093/carcin/bgac086
  5. Ohhata T*, Suzuki M, Sakai S, Ota K, Yokota H,UchidaC, Niida H, Kitagawa M.: CCIVR facilitates comprehensive identification of cis-natural antisense transcripts with their structural characteristics and expression profiles. Sci Rep. 12(1):15525, 2022. doi: 10.1038/s41598-022-19782-5.
  6. Koyauchi T, Niida H*, Motegi A, Sakai S,UchidaC, Ohhata T, Iijima K, Yokoyama A, Suda T, Kitagawa M.: Chromatin-remodeling factor BAZ1A/ACF1 targets UV damage sites in an MLL1-dependent manner to facilitate nucleotide excision repair. Biochim. Biophys. Acta Mol. Cell Res. 1869(11):119332, 2022. doi: 10.1016/j.bbamcr.
  7. Tamura Y, Ohhata T*, Niida H, Sakai S,UchidaC, Masumoto K, Katou F, Wutz A, Kitagawa M*.: Homologous recombination is reduced in female embryonic stem cells by two active X chromosomes. EMBO Rep. 22(9):e52190, 2021, doi: 10.15252/embr.202052190.
  8. Ohhata T*, Yamazawa K, Miura-Kamio A, Takahashi S, Sakai S, Tamura Y, UchidaC, Kitagawa K, Niida H, Hiratani I, Kobayashi H, Kimura H, Wutz A, and Kitagawa M: Dynamics of transcription-mediated conversion from euchromatin to facultative heterochromatin at the Xist promoter by Tsix. Cell Reports. 34, 108912, 2021, https://doi.org/10.1016/j.celrep.2021.108912
  9. Kitagawa K*,UchidaC, Horiguchi R, Ohhata T, Sakai S, Niida H, Yasumoto S, Handa Y, Suzuki M, Hashimoto M, Tazawa T, Yokochi Y, Tsuji M, Kitagawa M*.: Substitution of Thr572 to Ala in mouse c-Myb attenuates progression of early erythroid differentiation. Sci Rep. 10(1):14381. 2020, doi: 10.1038/s41598-020-71267-5.
  10. Nishimoto K, Niida H*,UchidaC, Ohhata T, Kitagawa K, Motegi A, Suda T, Kitagawa M.: HDAC3 Is Required for XPC Recruitment and Nucleotide Excision Repair of DNA Damage Induced by UV Irradiation. Mol. Cancer Res. 8(9):1367-1378, 2020. DOI: 10.1158/1541-7786.MCR-20-0214.
  11. Sakai S, Ohhata T,Kitagawa K, UchidaC, Aoshima T, Niida H, Suzuki T, Inoue Y, Miyazawa K, Kitagawa M*: Long noncoding RNA ELIT-1 acts as a Smad3 cofactor to facilitate TGF-β/Smad signaling and promote epithelial-mesenchymal transition. Cancer Res. 79(11) 2821-2838, 2019, doi: 10.1158/0008-5472.CAN-18-3210.
  12. Mikamo M, Kitagawa K, Sakai S, UchidaC, Ohhata T, Nishimoto K, Niida H, Suzuki S, Nakayama KI, Inui N, Suda T, Kitagawa M*: Inhibiting Skp2 E3 ligase suppresses bleomycin-induced pulmonary fibrosis. Int J Mol Sci 19(2): E474-491, 2018. Doi:10.3390/ijms19020474
  13. Niida H*, Matsunuma R, Horiguchi R, UchidaC, Nakazawa Y, Motegi A, Nishimoto K, Sakai S, Ohhata T, Kitagawa K, Moriwaki S, Nishitani H, Ui A, Ogi T, Kitagawa M.: Phosphorylated HBO1 at UV irradiated sites is essential for nucleotide excision repair. Nat Commun. Jul 18;8:16102. doi: 10.1038/ncomms16102, 2017.
  14. Harada M, Sakai S, Ohhata T, Kitagawa K, Mikamo M, Nishimoto K, UchidaC, Niida H, Kotake Y, Sugimura H, Suda T, Kitagawa M.: Homeobox Transcription Factor NKX2-1 Promotes Cyclin D1 Transcription in Lung Adenocarcinomas. Mol Cancer Res. Oct;15(10):1388-1397, 2017.
  15. UchidaC: Roles of pRB in the Regulation of Nucleosome and Chromatin Structures. Biomed Res. Int. Volume2016, Article ID5959721, 2016. Doi: 10.1155/2016/5959721
  16. Kotake Y, Kitagawa K, Ohhata T, Sakai S, UchidaC, Niida H, Naemura M, Kitagawa M: Long Non-coding RNA, PANDA, Contributes to the Stabilization of p53 Tumor Suppressor Protein. Anticancer Res. 36(4):1605-1611, 2016.
  17. UchidaC, Kitagawa M: RING-, HECT-, and RBR-type E3 Ubiquitin Ligases: Involvement in Human Cancer. Curr. Cancer Drug Targets 16(2):157-174, 2016.
  18. Sakai S, Miyajima C, UchidaC, Itoh Y, Hayashi H, Inoue Y: Tribbles-Related Protein Family Members as Regulators or Substrates of the Ubiquitin-Proteasome System in Cancer Development. Curr. Cancer Drug Targets 16(2):147-156, 2016.
  19. Matsunuma R, Niida H, Ohhata T, Kitagawa K, Sakai S, UchidaC, Shiotani B, Matsumoto M, Nakayama KI, Ogura H, Shiiya N, Kitagawa M: UV Damage-Induced Phosphorylation of HBO1 Triggers CRL4DDB2-Mediated Degradation To Regulate Cell Proliferation. Mol Cell Biol. 36(3): 394-406, 2015.
  20. Nakajima T, Kitagawa K, Ohhata T, Sakai S, UchidaC, Shibata K, Minegishi N, Yumimoto K, Matsumoto A, Nakayama KI, Masumoto K, Katou F, Niida H, Kitagawa M: Regulation of GATA binding protein 2 levels via ubiquitin-dependent degradation by Fbw7: involvement of cyclin B-cyclin-dependent kinase 1-mediated phosphorylation of Thr176 in GATA binding protein 2.?J. Biol. Chem. 290:10370-10381, 2015.
  21. UchidaC, Hattori T, Takahashi H, Yamamoto N, Kitagawa M, Taya Y: Interaction between RB protein and NuMA is required for proper alignment of spindle microtubules. Genes Cells. 19: 89-96, 2014.
  22. UchidaC: The retinoblastoma protein: Functions beyond the G1-S regulator. Curr Drug Targets 13: 1622-1632, 2012.
論文
  1. Nakazawa M., Hayashi S., Tanaka K., Iwasaki K., Goda M*., Yamada Y*., Adachi N*. Semi-automated MicroED system unveils multiple polymorphs in fish-derived guanine crystals. Acta Crystallogr. C Struct. Chem. 82(7) doi:10.1107/S2053229626006236 (2026)
  2. Goda M., Miyagi A., Sugiwaka K., Watanabe M., Bessho-Uehara M., Hibi M., Toyoda A., Tanaka R., Mesengi WA K., Yamahira K., Ansai S., Hashimoto H*. A simple method for RNA-seq of manually-isolated chromatophores in Oryzias fishes. Dev.Growth.Diff.68(3) e70044 (2026)
  3. Goda M., Shribak M., Ikeda Z., Okada N., Tani T., Goshima G., Oldenbourg R., Kimura A*. Live-cell imaging under centrifugation characterized the cellular force for nuclear centration in the Caenorhabditis elegans embryo. Proc. Natl. Acad. Sci. USA 121(43) e2402759121 (2024)
  4. Goda M*., Miyagi A., Kitamoto T., Kondo M., Hashimoto H. Uric acid is a major chemical constituent for the whitish coloration in the medaka leucophores. Pigment Cell Melanoma Res. 36(5): 416-422 (2023)
  5. Goda M*. and Ohta I. Morphological features of novel chromatophore unit in the upside-down catfish,Synodontis nigriventris. J. Electr. Microsc. Technol. Med. Biol. 33 (1):36-37 (2020)
  6. Goda M*. Rapid integumental colorchanges due to novel iridophores in the chameleon sand tilefish Hoplolatilus chlupatyi. Pigment Cell Melanoma Res. 30: 368-371 (2017)
書籍
  1. Goda M., Kimura A. A Centrifuge Polarizing Microscope (CPM) that Enables the Visualization of Intracellular Structures Under High Centrifugal Forces. In: Kiyomitsu T. (Editor) The Mitotic Spindle: Methods and Protocols pp.75-85 Springer (2025)
  2. 合田 真、高橋明義. 「動物の体色がわかる図鑑」第4章 魚類の体色 グラフィックス社（東京） p.198-215 (2022)
  3. Goda M., Kuriyama T. Physiological and morphological color changes in teleosts and in reptiles. In: Hashimoto H., Goda M., Futahashi R., Kelsh RN., Akiyama T. (Editors) Pigments, Pigment Cells and Pigment Patterns. p.387-424 Springer (2021)
  4. Hashimoto H., Goda M., Kelsh RN. Pigment cell development in teleosts. In: Hashimoto H., Goda M., Futahashi R., Kelsh RN., Akiyama T. (Editors) Pigments, Pigment Cells and Pigment Patterns. p.209-246 Springer (2021)
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